#1

This was suggested by adssx in another thread. Simple concept. but potentially very powerful to help us reduce and optimize our drug intakes. Just comment on others drug stacks. Suggest things that can be eliminated, or weigh in on efficacies and synergies.

Please post your own stacks.

My stack as of 12/18/2024 (I am 47 male) items taken daily unless otherwise stated

  1. 6mg weekly rapamycin
  2. 20mg atorvastatin
  3. 5mg ezetimibe
  4. 180mg bempedoic acid
  5. 12.5mg empagliflozin
  6. 200mg acarbose split between 2 meals
  7. 5mg tadalafil
  8. 80mg telmisartan
  9. 100mg ubiquinol
  10. 200mg magnesium from glycinate
  11. 2g magtein
  12. 500mg citicoline
  13. 50mg theanine
  14. methylated multivitamin
  15. ADK with 900mcg retinyl palmitate, 5000IU D, 1mg K1, 1.8 mg K2
  16. Omega 3 2 grams (triglyceride form, 2.5/1 EPA/DHA ratio)
  17. 500mg vitamin c
  18. 3 grams taurine
  19. 5 grams creatine
  20. 6 grams glycine
  21. 2 grams NAC

Probably forgetting a few things, this was from memory.

19 Likes
#2

EPA? DHA? Which form (ethyl ester?)?

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#3

The omega I currently take is Sports Research Triple Strength Omega 3 Fish Oil. Triglyceride form, 2.5/1 EPA/DHA ratio. Helped lower my blood triglyceride levels significantly. Puts me at 10 on the omega quant index.

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#4

I mean, being both ruthless AND dishonest would be for overachievers here :wink:

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#5

My question would be about the statin and ezetimibe, and bempedoic acid. Do you have a documented lipid problem?
I dont eat carbs so no need for acarbose and the accompanying misery. Otherwise looks pretty comprehensive.

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#6

Yes I do. High Lp(a), Triglycerides, LDL. With this combo, my LDL is below 50 now. It was at 147 before treatment.

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#7

Right off the bench here I’d say get that heart balance test to see where to focus most — are you and overproducer or over absorber or something in the middle? Sounds like you just throw the kitchen sink at it otherwise.

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#8

Hmmm… no proscar - finasteride?

Suggest 5 mg daily every other day… good luck with the prostate as you hit 50… then 60.

Any potential ED concerns will be balanced by your daily tadalafil.

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#9

Yeah I wanted to throw the kitchen sink at it! My LDL was around 150, ApoB at 145. In most people who overproduce, they still get benefit from ezetimibe. And vice versa. Thanks for commenting, hope some others post their stack

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#10

We have discussed this a little in another thread. It is one thing I am considering adding, My PSA is 0.6 which I am happy with for age 47, but I definitely want to look into trying it.

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#11

I’d say tadalafil, empagliflozin, and rapamycin are the riskiest ones in your stack in terms of rare but freaky side effects and in order of expected efficacy from lowest to highest. Priapism for tadalafil, genital infections for empagliflozin, and overall infections for rapamycin. Out of those 3 I’d guess rapamycin has the better risk vs. reward at a relatively moderate dose of 5 or 6 mg one time a week.

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#12

At almost 67 years… my PSA is .78

Good choice for clearing cholesterol in blood too.

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#13

So far so good on tadalafil, been taking it for years, never had priapism. So far so good on no genital infections (I keep good hygiene, and more of an issue for women afaik). Yeah rapamycin no side effects so far, but only been on it a couple months.

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#14

Read from here, it’s something that would require decompression (with permanent side effects). Probably is riskier off-label without ED.

It seems extremely rare to have serious infections: FDA Drug Safety Podcast: FDA warns about rare occurrences of a serious infection of the genital area with SGLT2 inhibitors for diabetes | FDA

But combination of it and rapamycin probably is not as good as one or the other for risk although hard to quantify. I think I overestimated this risk and it’s lower (for serious ones) when used on its own.

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#15

As said in the other thread about Q10: I’m not sure ubiquinol is beneficial (could be detrimental).

Multi vit: make sure B6 is not too high. And B9 might lower lifespan later in life.

Other compounds: no opinion or seems OK to me.

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#16

Yeah I have the same concern about ubiquinol, there are just so many conflicting studies. My rationale is that I take a moderate dose statin and do not want my coq10 depleted. I need to do more reading on the possible detrimental effects as far as statin/non-statin users.

The way I see it now is, on 20mg atorvastatin and 100mg coq10 I get no myopathy. I could eliminate the coq10 and see how the myopathy is. Not sure I want to bother with that, but will consider the experiment.

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#17

There’s not even evidence in statin users for muscle pain. You could also stop ubiquinol, lower atorvastatin to 10 mg and increase ezetimibe to the normal 10 mg.

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#18
  1. I’m not convinced of low dose rapamycin. 20-30mg once every two weeks or monthly could potentially be better.
  2. Solid choice
  3. Also good and more affordable than 10mg
  4. Solid choice
  5. Solid choice
  6. Aren’t you worried about too low blood sugar levels if you combine it with empa?
  7. Fine if you don’t experience side effects
  8. Potentially high dose
  9. I’d rather use low dose ubiquinol to compensate for atorvastatin
  10. More magnesium
  11. ?
  12. How much raw choline does this contain?
  13. Do you use it for sleep?
  14. Solid choice but make sure it doesn’t contain vitamin A or E.
  15. Potentially too much vitamin A
  16. Could be a bit too much omega 3
  17. Okay dose
  18. Good dose, could be higher
  19. Good dose
  20. Okay doe
  21. I’d cycle NAC

Potentially missing astaxanthin, zeaxanthin, lutein, a 5ar inhibitor, hyaluronic acid, collagen and lycope.

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#19

I reduced my dose on Fish Oil since the A. Fib linkage came out. I do tons of cardio so I am at risk as it is.

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#20

What level of omega 3 are you at now?