#41

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Lp(a), ApoB, HbA1c and a full hormone check-up is coming next
Pretty happy about the results. Lipids are amazing, almost no triglycerides, LDL is low. Liver is great even with all the meds and statin!
FBG is almost too low!

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#42

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Low albumin and phosphatase alkaline might be due to plasma donation. HBA1C is my lower, wich is weird when we know what my FBG is and that Iā€™m on 3 antidiabetic medications. I suspected my RBC to live longer that normal.
Testosterone has increased and prolactin has lowered. DHT on the road, with SHBG and zinc.
Lab forget few tests I ordered. New blood work to do to completeā€¦ (ApoB, ApoA1, Lp(a) )

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#43

My PSA is 1.7. Iā€™m not happy with that. :frowning: I have a moderately enlarged prostate and a history of prostate cancer in my family. My father survived it. My grandfather didnā€™t.

#44

PSA is another biomarker that has a base level and can go up from time to time if there is some disturbance or other.

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#45

So great news!
ApoA is 1.59 g/L
ApoB is 0.39 g/L

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#46

Are you on finasteride or Cialis at all and did they make a difference if you were taking them?

#47

For those taking Finasteride, please understand that it skews PSA numbers. PSA levels in men taking finasteride should typically be doubled to approximate the true PSA value.

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#48

I donā€™t take Finasteride. I tried, but the side effects were too severe - depression and my testicles hurt.

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#49

I also am in risk category, and I do 5mg Cialis (for that reason only) but wanted to try finasteride. Knock on wood so far ,mine is 0.80 psa at 58, and hasnā€™t moved in last five years. I think you had indicated you are doing 5mg Cialis also. Wonder how long you have been doing it and if it made a difference at all on your PSA. If I were you, I would try Finasteride again (since you are in high risk) and hopefully your sides will go away. Start very low, maybe 1mg initially.
We have to make sure we beat that effing PC bastard. It is a disgusting disease. Iā€™m going to watch mine closely every year and the moment it near 1 Iā€™m going to do Finasteride.

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#50

I have ordered Cialis and will begin this summer. I do take a little Finasteride every Monday. That seems tolerable. Maybe I need to try Monday and Thursday.

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#51

Did you ever try dutasteride? Itā€™s considered a stronger 5ari, and also a more effective hair loss treatment. Lots of people report getting sides from Finasteride and switching to dutasteride and having none.

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#52

Whatā€™s the recommended dosing for dutasteride for PC prevention?

And hair loss? :wink:

#53

My Longevity Journalā€¦ 28 Years Later

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#54

0.5mg daily. I got an Rx and may try switching soon.

Although Iā€™ve been on finasteride for 2yrs and had no obvious sides, I wonder if thereā€™s a more subtle negative effect. Thereā€™s some recent work showing that finasteride inhibits human PNMT (which converts norepinephrine to epinephrine), and this was confirmed in vivo in rat adrenal glands. Source: Finasteride inhibits epinephrine synthesis in humans: implication for sexual dysfunction | ECE2022 | European Congress of Endocrinology 2022 | Endocrine Abstracts

Given the many variety of roles norepinephrine plays in the brain (certainly it plays a much larger role than androgens), it wouldnā€™t be surprising if finasterideā€™s sides are generally caused not by 5ari, but instead by altered neurotransmitter metabolism. This would square with the fact that many get sides from fin but not dut.

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#56

My PSA .78 my age 66 yrs. 8 months.

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Have been taking proscarā€¦ finasteride for 34 yearsā€¦ 5 mg most days.

For keeping hair, small prostateā€¦ and clearing cholesterol from blood. Winā€¦winā€¦win!

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#57

Ha ha ha, maybe just a little less CR and I donā€™t know what to say about your skin. Sorry.

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#58

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No need for finasteride! Naturally low DHT level!
Low zinc too, Iā€™m going to increase my dosage from 25 to 50mg a day. It may come from plasma donation

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#59

Pinging hair loss witcher and expert @Virilius what he thinks about this.

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#60

Low but still within the reference range. On 1mg/day and mine tested 9.6 ng/dL, so over 3x lower than yours. My free DHT was 1.34 pg/mL, which is also lower than the reference range (2.3-11.6). Total testosterone (760) was within range.

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#61

Serum DHT levels are not a good proxy for hair follice and prostate DHT levels. Even assuming low DHT levels at the respective tissue, there could still be an overdensity of androgen receptors so DHT levels would have to be crushed even lower.
The best way to assess whether DHT is sufficiently low would be to monitor for hair follicle miniaturization and prostate enlargement. In some cases, not even finasteride suffice in which case one would have to use dutasteride at doses ranging from 0.5-5mg.

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