59vw
#122
Yes, Pomelo is even more potent than grapefruit at inhibiting CYP3A4. I can’t seem to find them in the stores that often though and like to stick to a routine.
José
#123
People who like grapefruit.
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I live on the edge of inner city birmingham with a wide range of shops serving different ethnicities and ordinarily stocking pomelo and other otherwise unusual fruits.
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I see them frequently in the Chinese markets (Chinatown, other areas) in San Francisco. But I’m fine with grapefruit, so don’t usually buy them.
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SNK
#126
If grapefruit has such a big effect in absorption of RAPA (as an example) wouldn’t it interfere with other medicines and even various nutrients also?
Since i learned that grapefruit multiplies the absorption of RAPA you can rest assured, I’ll never touch it again, other than when I take RAPA. You don’t need to be a doctor to understand that it messes up your system.
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José
#127
Yes it does.
This has been discussed on this fourum on many threads.
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SNK
#129
I was looking for something more specific. i.e lets say i eat grapefruit as desert will it affect the way nutrients from the meal are absorbed? and is there any case that it is a good idea to eat grapefruit for certain purpose (other than to increase medicine absorption). I’m more interested in food and nutrient digestion effects if any.
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adriank
#130
Just got my results. The lab toxicologist panicked and wanted to admit me into the hospital. My 26mg with 3 Grapefruit after 2 hours yielded 27.2ng/mL and after 24 hours 9.7ng/mL and I’ll do one more test after 7 days.
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Much that I will stick to my 6mg (or 5 depending on packet) plus Pomelo, there has been an N=1 experiment with more than you took and we have not seen any immediate problems although I would expect mTOR to be inhibited for quite a while.
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adriank
#132
Based on the Blueprint Protocol, I think 27.2 is in the correct target range. Maybe I will drop it back a notch to 24mg / 6mg with at least 500ml of GFJ or 2 grapefruit or 1 pamelo plus 1x 100mg aspirin. I still do not like GFJ or grapefruit that much. Pamelo is far more palatable. Now I will see how my arthritis goes after 6 months.
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SNK
#133
don’t expect much for that. It didn’t do zippo for my arthritis, but hopefully you case will be different.
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I bought some #0 enteric caps …you can put two Siroboon tabs in one.
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If you do any blood sirolimus testing to see if it improves bioavailability, please post your results.
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adriank
#137
After 1 week my blood level is 2.4ng/mL. The next day I took 6mg with 2 grapefruit and after 75 minutes it yield 3ng/mL.
I’m waiting for the enteric capsules to arrive and I’ll have these pills inside the capsules and see what happens.
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Justin
#138
Be careful about your own CYP enzymatic make-up!
About 12 years ago I was on simvastatin and developed community pneumonia. I went to a local clinic. He put me on erythromycin, and never checked what else I was on. Well, simvastatin + erythromycin are strong inhibitors of the CYP3A4. One was fine—two was definitely not.
The next afternoon at work I started feeling horrid and did some research on erythromycin and saw the two really were incompatible. I had a multistrip in my clinic (I’m an RN) and the indicator for blood in urine when solid black, instantly. But there was no blood in my urine. There was however, myoglobin. I had Rhabdomyolysis! Luckily there appears to be no major damage done. Had I kept taking the erythromycin, in a day or three, my liver would have been destroyed.
The pharmacist at CVS said: “The computer should have pinged me when it saw that you were on simvastatin.”
I later found that exactly the same thing happened to my niece. Therefore, I think it’d be wise that I consider going very slowly with the grapefruit juice. Anyone else with similar experience?
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adriank
#139
The last result is a bit unusual. I had 500ml of GFJ from the bottle. About 1.5hr later I had the 100mg aspirin and some breakfast with my wife consisting of half a garlic bread with avocado. After that on the 2hr mark I had 13x 2mg pills doused in hemp oil. 24.5 hours later I returned a result of 18.2 ng/L. I didn’t even feel tired.
Previously 2 weeks ago, my 24 hour test yield 9.7ng/L. And I felt fatigue on the first day. The only different this time is I had more food, and GFJ from the bottle and took the rapamycin around 10.30am instead of 8am.
Next week I’ll take 12mg encased in enteric capsules blanks I bought and try to repeat what I did this week.
23/04/2024
See how I go this week with my blood test. The only question is should I put the hemp oil into the capsules or take them separately? I’m planning to have it separately to maintain the integrity of the capsules.
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It seems like a lot of work to replicate the results we would normally get by using Rapammune, Zydus or Biocon brands.
To me, Siroboon isn’t worth the effort.
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adriank
#141
I think the problem is Australia Border Security not allowing me to order anymore rapamycin until August. Anyway it is interesting and keeps my mind busy lol.
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