#123

People who like grapefruit.

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#124

I live on the edge of inner city birmingham with a wide range of shops serving different ethnicities and ordinarily stocking pomelo and other otherwise unusual fruits.

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#125

I see them frequently in the Chinese markets (Chinatown, other areas) in San Francisco. But Iā€™m fine with grapefruit, so donā€™t usually buy them.

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#126

If grapefruit has such a big effect in absorption of RAPA (as an example) wouldnā€™t it interfere with other medicines and even various nutrients also?

Since i learned that grapefruit multiplies the absorption of RAPA you can rest assured, Iā€™ll never touch it again, other than when I take RAPA. You donā€™t need to be a doctor to understand that it messes up your system.

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#127

Yes it does.

This has been discussed on this fourum on many threads.

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#128
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#129

I was looking for something more specific. i.e lets say i eat grapefruit as desert will it affect the way nutrients from the meal are absorbed? and is there any case that it is a good idea to eat grapefruit for certain purpose (other than to increase medicine absorption). Iā€™m more interested in food and nutrient digestion effects if any.

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#130

Just got my results. The lab toxicologist panicked and wanted to admit me into the hospital. My 26mg with 3 Grapefruit after 2 hours yielded 27.2ng/mL and after 24 hours 9.7ng/mL and Iā€™ll do one more test after 7 days.

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#131

Much that I will stick to my 6mg (or 5 depending on packet) plus Pomelo, there has been an N=1 experiment with more than you took and we have not seen any immediate problems although I would expect mTOR to be inhibited for quite a while.

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#132

Based on the Blueprint Protocol, I think 27.2 is in the correct target range. Maybe I will drop it back a notch to 24mg / 6mg with at least 500ml of GFJ or 2 grapefruit or 1 pamelo plus 1x 100mg aspirin. I still do not like GFJ or grapefruit that much. Pamelo is far more palatable. Now I will see how my arthritis goes after 6 months.

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#133

donā€™t expect much for that. It didnā€™t do zippo for my arthritis, but hopefully you case will be different.

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#134
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#135

I bought some #0 enteric caps ā€¦you can put two Siroboon tabs in one.

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#136

If you do any blood sirolimus testing to see if it improves bioavailability, please post your results.

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#137

After 1 week my blood level is 2.4ng/mL. The next day I took 6mg with 2 grapefruit and after 75 minutes it yield 3ng/mL.

Iā€™m waiting for the enteric capsules to arrive and Iā€™ll have these pills inside the capsules and see what happens.

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#138

Be careful about your own CYP enzymatic make-up!

About 12 years ago I was on simvastatin and developed community pneumonia. I went to a local clinic. He put me on erythromycin, and never checked what else I was on. Well, simvastatin + erythromycin are strong inhibitors of the CYP3A4. One was fineā€”two was definitely not.

The next afternoon at work I started feeling horrid and did some research on erythromycin and saw the two really were incompatible. I had a multistrip in my clinic (Iā€™m an RN) and the indicator for blood in urine when solid black, instantly. But there was no blood in my urine. There was however, myoglobin. I had Rhabdomyolysis! Luckily there appears to be no major damage done. Had I kept taking the erythromycin, in a day or three, my liver would have been destroyed.

The pharmacist at CVS said: ā€œThe computer should have pinged me when it saw that you were on simvastatin.ā€

I later found that exactly the same thing happened to my niece. Therefore, I think itā€™d be wise that I consider going very slowly with the grapefruit juice. Anyone else with similar experience?

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#139

The last result is a bit unusual. I had 500ml of GFJ from the bottle. About 1.5hr later I had the 100mg aspirin and some breakfast with my wife consisting of half a garlic bread with avocado. After that on the 2hr mark I had 13x 2mg pills doused in hemp oil. 24.5 hours later I returned a result of 18.2 ng/L. I didnā€™t even feel tired.

Previously 2 weeks ago, my 24 hour test yield 9.7ng/L. And I felt fatigue on the first day. The only different this time is I had more food, and GFJ from the bottle and took the rapamycin around 10.30am instead of 8am.

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Next week Iā€™ll take 12mg encased in enteric capsules blanks I bought and try to repeat what I did this week.

23/04/2024

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See how I go this week with my blood test. The only question is should I put the hemp oil into the capsules or take them separately? Iā€™m planning to have it separately to maintain the integrity of the capsules.

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#140

It seems like a lot of work to replicate the results we would normally get by using Rapammune, Zydus or Biocon brands.

To me, Siroboon isnā€™t worth the effort.

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#141

I think the problem is Australia Border Security not allowing me to order anymore rapamycin until August. Anyway it is interesting and keeps my mind busy lol.

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#142

I am glad you keep trying. I have quite a lot of Siriboon and if I get my new supply of Biocon interrupted, it will be my fall-back. My approach was to take a LOT of it, like 20 mg prior to my getting a shipment of Biocon.

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