Siroboon Sirolimus / Rapamycin Lab Blood Test Results

[Alex]

I am glad you keep trying. I have quite a lot of Siriboon and if I get my new supply of Biocon interrupted, it will be my fall-back. My approach was to take a LOT of it, like 20 mg prior to my getting a shipment of Biocon.

[adriank]

Latest result with 12mg in enteric capsule.

In my observation having the pills an hour or 2 after food yields a higher result.

[adriank]

I know someone who takes like 24mg of zydus weekly. Lol

[DeStrider]

24 mg of Zydus a week is a bit much. He may be inhibiting his MTORC2 at those levels. We do know that levels of 20 mg and below do not typically inhibit MTORC2. At 40 mg, it’s a 50/50 proposition.

[adriank]

I’m tempted to stick with 12mg a week with the enteric capsules. Anyway I’ll check again for the next 2 weeks and decide.

[RapAdmin]

@adriank

24mg of zydus weekly.

Any side effects? Hopefully the person gets their blood checked… regularly.

[adriank]

apparently that dosage suppresses the psoriasis. If my 12mg does not do anything, I will resort to that.

[adriank]

Just had 12mg 6x2mg earlier today which I put into the enteric capsules. I tried to finish the remainder of the GFJ but it appears to be more than 600ml. It has been 4 hours and I’m actually feeling a bit more tired than usual. These capsule must be working and extra GFJ definitely affects it. Tomorrow I’ll get the 24hr blood test and by Friday I’ll have the results.

Update

24 hour test comes in at 10.1 ng/L

So it seems more GFJ does affect it. That means the peak is over 30+

I think I’ll maintain this level for a few weeks and see how my psoriasis goes and observe of there are any other effects.

The enteric capsules definitely helps. They are very cheap. Like 200 for $15aud. Allows me to reduce from 26mg to 12mg. Eating my scrambled eggs with hemp oil and bread also helps . From now on I’ll do 1 glass of GFJ 2 to 3 hours before. Then when I have my breakfast an hour before I’ll add another glass of GFJ. I’m sure I’m total more than 500ml of GFJ. GFJ cost $6 per bottle of 1.5L here. I still don’t like them. But for the greater health . My supply should last 1.5 years at this rate. I’ll extent the weekly to 8 days or longer depending how well the psoriasis behaves. Hopefully I’ll have enough data to convince the local medical institution to allow me to buy locally which is a lot cheaper and higher quality. $30aud per 100 rapamune 1mg.

[adriank]

Either I am getting the dosing wrong or the psoriasis is not diminishing as quickly as I like. Some ppl suggest upping my Vitamin D3 to 3000 IU which I will try. Also, I just got offered 5mg Siroboon tablets for $1.5 each… hmmmm that is cheap. I will only need 2 to be placed into my enteric capsule. Any thoughts?

[RapAdmin]

I wouldn’t bother with Siroboon… their quality just seems far too questionable to bother with. You really have no idea what the dosing is with that company. Many people have reported extremely poor results with their sirolimus. I would only buy Zydus or Biocon because at least you know what dose you’re actually taking.

[adriank]

i better get it locally then… somehow have to convince someone to give me a script…

[DeStrider]

Just buy Zydus or Biocon from India. Not Siroboon.

I have bought both from India. Although I kind of prefer Zydus.

[John_Hemming]

I have been alternating between zydus and biocon.

[adriank]

I prefer to buy them locally if I can. See what I can come up with. I now have a history of my blood test showing I have been on siromilus so hopefully some unsuspecting GP will prescribe it to me. lol

[Vandegraaff]

Another bad lab test result for Siroboon 2mg tabs. I bought these before reading suspect reports of Siroboon quality. As experiment, I took 4mg (2 tabs), plus 4 oz of fresh squeezed grapefruit juice. Took blood draw for Quest Sirolimus blood test, exactly 2 hrs later. Very low result of 2.5ng/L l when I was expecting 15-20. Do not buy Siroboon. I switched to Zydus 1mg, and based on lab results I am confident they are good. Threw away Siroboon junk.
PS. Sirolimus needs a controlled, low temp environment. India gets hot.
It could be due to environmental issues degradation. I keep min in the frig.

[RapAdmin]

Here (below) is the temperature advisory from Pfizer for rapamune… room temp is fine, but yes, the heat in India (at least recently) probably isn’t good and I wonder if the Pharma stores these in temperature controlled warehouses…

Source: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/021083s059,021110s076lbl.pdf

[adriank]

I have not got a choice but to use it… regardless even with the irregular readings… my joint pains have disappeared almost completely. My allergies so far is also almost gone. Both very noticeable. I get more consistency by using the enteric capsule to hold the pills in…

[Ryan1]

I have been using SiroBoon for a year now and luckily stumbled on this post. To check my blood, I did the following:

7 am ate a medium grapefruit with 100 mg Acarbose

11 am ate a medium gf w/ 150 mg Acarbose followed by an Italian sub sandwich

11:30 am 3 x 3 mg siroboon for 9 mg total

1:45 pm blood draw at Labcorp = 3.8 ng/mL

Disappointed to say the least. I have tried zydus and rapacan before siroboon. I was a little skeptical because of the price. I just ordered more rapacan, so we will see in a few weeks once I get it.

[adriank]

I think you should wait at least 12 or 24 hours before you get the blood test. I had the same results before, but at 12 and 24 hours the blood test is within limits. When I take 8mg, after 3.5days I got my blood test it returned 3.9ng/mL. But I take 750ml of GFJ with a meal and wait 3 hours before having my rapamycin.

[Ryan1]

I will order some enteric capsules and try that in the meantime, but I think I’m over siroboon. Lab tests aren’t cheap for me and it seems inconsistent/weak. If I get a good result with rapacan I’m just going to stick with it.