#11

I’d like to she her compare with and without the Novos.

#12

Here is what Vera-Health.ai says on face age and health outcomes.

I agree with @KarlT on seeing if the Novos supplement has anything to do with her Dunedin pace and then does Dunedin pace actual work prospectively?

The apparent age of an individual’s face can indeed correlate with certain health outcomes. Facial aging is influenced by factors such as genetics, environmental exposure, lifestyle choices, and underlying health conditions. While the perception of age can be subjective, studies have shown that looking older than one’s chronological age might be associated with poorer health outcomes.

Research suggests that individuals who appear older than their chronological age might be at higher risk for certain health conditions. For example, perceived facial age is associated with an increased risk of cardiovascular disease and mortality. Individuals who look older may have a higher risk of heart disease and stroke. Additionally, facial aging, particularly in women, has been linked to lower bone mineral density and an increased risk of osteoporosis. Accelerated facial aging has also been associated with poorer cognitive performance and an increased risk of dementia.

Moreover, facial aging can sometimes reflect underlying systemic diseases. For instance, endocrine disorders or malnutrition can lead to changes in facial appearance. Furthermore, certain genetic syndromes that affect aging, like Werner syndrome, are associated with both accelerated facial aging and early onset of age-related diseases.

It is important to note that while these correlations exist, they do not imply causation. Not everyone who appears older will have health problems, and not everyone with health problems will appear older. The perception of age can vary widely among observers, and facial appearance is just one of many indicators of overall health.

In summary, while facial age can correlate with some health outcomes, it should not be used in isolation to assess health risks. A comprehensive evaluation that includes medical history, lifestyle factors, and clinical assessments is essential for accurately determining an individual’s health status.

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#13

“If one skin treatment makes you 25 years younger per Novos face clock then Novos is quite inaccurate”

It’s not a one skin treatment, but consistent treatments for many years. My point is that the Novos app doesn’t take that into consideration. It cannot distinguish between natural vs artificial face aging. My age is 69, but the facial wrinkles score (because of treatments) is 100/100, which means no wrinkles at all. Therefore, it assesses my age as 35-40. It unfortunately doesn’t make my organs younger.

Novos Faceage was probably designed for natural faces only (no facelift, no other surgical procedures, no fillers, etc)

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#14

Just curious and trying to understand Novos face clock accuracy a bit better- so people who meet you in person and don’t know your age, do they think you are 35-40 ?

#15

Ppl who meet me in person think that I’m under 50. Novos app evaluates only face. Ppl see the whole picture.

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#16

I posted a good article on what DunedinPACE is measuring today, for those who don’t understand the how and why of it. It’s really no different than any of our other blood tests, you can have great BP and crappy cholesterol, perfect WBC and bad HbA1c. Different tests results from different functions.

Like aging, with it’s 12 or 13 Hallmarks, 1 test does not reveal the whole story.

PACE is just one test that with all the data it was developed from is an indicator of potential health and life span. It doesn’t tell you what you are going to die from or what you need to change to stay healthy. For many I can see that it would be irrelevant, especially if one is working on that “one thing” they know is going to kill them, like they have cancer or are at risk for AD because of their genetics, etc.

Our experience is that both my wife and I are on the same programs/interventions, we eat the same food, drink the same water, are close in physical activity, I sleep a lot better than she does, we breathe the same air. She absolutely kicks my butt in all epigenetic tests, including PACE.

So yes, genes and sex make a difference. Those 2 parameters alone show differences in many, many trials. So no one should be surprised if a female is ahead of a bunch of Bro’s…

#17

Thank you!!! I love them. Definitely give them a try.

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#18

I’ve been “bio-hacking” for longevity since 2017 when I first learned about the term - longevity. However, I’ve been bio-optimizing since I was 30 and really seriously in my 40’s when I discovered I had heavy metal poising, despite following what I thought was a healthy lifestyle.

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#19

I agree wholeheartedly. The requirement of 3 tests within 24 months makes this economically prohibitive for so many people - and usually the people that might need the change the most.

JUST FYI - there were 3 tests:
0 months with no NOVOS = 0.76 pace
6 months with NOVOS = 0.68 pace
12 months with NOVOS = 0.65 pace

Please note that the first 6 months I was taking NOVOS (Core and Boost) I was under extremely stressful family circumstances. There were no lifestyle or dietary optimization . In fact I’d say it was in the opposite direction in staying up several nights in a row to make sure my son was ok, and eating whatever, if I ate at all (there were weekly trips to In-n-Out for sure). It was truly the most stressful time of my life. So I attribute 8% slowing of my pace to NOVOS. The 2nd 6 months were calmer, and I implemented all the diet and lifestyle points from my website. I’m not selling NOVOS, just stating the facts.

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#20

Julie - great to have you here, and welcome to the site. Congratulations on your success in slowing your pace of aging, as measured by DunedinPace.

Everyone else - Julie is the person this initial post is all about.

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#21

I am not myself persuaded that the tests actually provide the information we need to judge health improvements. I do tend to try lots of different tests as I don’t have that tight a budgetary limit (in the sense that at the moment I am doing 2 blood panels a week).

However, I am unhappy with the aggregate costs of TruDiagnostic so I will accept gradually drifting down the leaderboard.

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#22

I agree. I can justify its use on an annual basis - but not more. I think there are so many clocks out there and new ones emerging that I’d be more inclined to see what they say. What I do like however, is the change. If we can add something to our protocol and see a change, that seems like useful info. I don’t vary my protocol much so not really useful to do - unless I add rapamycin, then Id be curious what 6 month on that addition would show.
Did you guys hear the podcast with Kara Fitzgerald (New Frontiers in Functional Medicine). She interviewed Dr. Matt Kaeberlein. He had a good synopsis of the state of the aging clocks. I also just learned about an inflammation agin clock that will come out soon too. Work by Dr. David Furman.

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#23

Thank you! Happy to answer any q’s that come up and welcome criticism. I think we’re all figuring this out together and we have lots to learn from each other. I will reply, it just may take me a bit. I’m more accessible on IG @juliegibsonclark But will be checking in here as I’m currently researching wether or not to add rapamycin.

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#24

@julsgc Welcome to the site! We’re a friendly group willing to help each other out in any way to live longer. I hope we can be of service to you and your endeavors. :slight_smile:

We’re probably the best source on the web for Rapamycin info.

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#25

A quick way to reduce your facial age on the NOVOS app is to smile. That took 2 years off my facial age. However, smiling added 2 years to my eye age.

The good news, is they’re both below my chronological age. Now I wonder how else I can contort my face into losing a few more years. :wink:

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#26

Rapamycin is quite complex as there are dosing uncertainties as well as timing uncertainties.

You will see these discussions on this forum. I tend to argue for a lower frequency of dosing because the idea is to do a spring clean of mitochondria.

I am currently running blood tests twice a week and a continuous glucose monitor following a large dose of rapamycin a couple of weeks ago. I will post the results of these once things have stabilised back to normal. (and I have the test results)

Rapamycin does change the metabolism whilst it remains in the system and it has a long half life.

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#27

I think the underlying rate of CRP is a good metric for inflammation. You need multiple measurements to be able to exclude the value when infected.

There was an interesting paper recently that looked at the acid-base balance. This was based on a previous one that concluded that age is linked to people being more acidic.

I have also recently tried the GlycanAge test and should get the results of that tomorrow.

DunedinPACE is reasonably reliable, but a problem with most methylation clocks is that they can vary from test to test on the same sample too much.

I think TruDiagnostic’s science is actually quite good, but is limited by the unreliabliity of DNA methylation as a metric.

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#28

I did this test back in 2023 and recently did it again (twice) The first report included details on what the measurements mean, with respect to their algo’s. The newer report is just the numbers with no explanation. My guess is that they want you to sign up for the more detailed explanation.

I did repeat the recent test a few days later with a different/newer picture and got a similar result.

I’m not sure how well this app has been validated but I’m sure there is a fair bit of variability.

Steve_M_face-age_novos_2023-09.pdf (711.4 KB)
Steve_M-face-age_Novos_2024-09_01
Steve_M-face-age_Novos_2024-09_02

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Face Photo Aging Apps to Track Skin Age Improvements
#29

How is your Novos facial age compared to your chronological age?

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#30

I’m 68 :slight_smile:

I’ve got to get my wife to do this, she is 67 and beats me in every DNAm test so far, so why not beat me in another one LoL!

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