o. Does “diabetic” in mice/rats mean type 1 (as in “no insulin production”)? Or does it mean high average blood glucose levels?
Reading the article would furnish the answer. The diabetes was induced.
Thirty-five of the rats were injected intraperitoneally with a single dose of streptozotocin (STZ; 65 mg/kg of bodyweight)
Three days after STZ administration, only the rats that have a blood glucose level of >15 mmol/l were considered as diabetic and were included in our experiments.
o. Is “L-glycine” the same as glycine we are all buying in kg bags? Or is it a derivative?
You could have done a search to make this a more collaborative exchange.
Summary – Glycine vs L Glycine
The key difference between glycine and L glycine is that glycine is an amino acid that makes up proteins, whereas L glycine is an isomer of glycine. When we talk about glycine, we actually talk about L glycine because it is the most stable and common form in biological systems. It is because our cells use only the L isomer. Further, this compound has many applications, including medicinal applications.
o. Is the mechanism for cataract prevention similar to preventing presbyopia? Meaning it (i think) should impact glycation in the eye lens specifically, which may have something to do with improving lens cell mitochondrial function?
The article’s conclusion provides the answer.
In conclusion, the present study shows that the administration of Gly to diabetic rats delays the onset and the progression of cataract by decreasing protein glycation, preserving protein content, potentiating the antioxidant system, and decreasing the activity of the polyol pathway in the lenses. Decreasing the serum Glc, AGE formation and HbA1c, in addition to the increase in the FRAP [Gly also increased the ferric reducing antioxidant power (FRAP) in the serum of diabetic rats.] are also other reasons for the beneficial effect of Gly on diabetic cataract. Gly did not show any toxic effect on the above-named parameters in the normal rats.
It is a short read. It would do justice to the scientists to read or skim their work in the original, instead of my summaries.
