#22

Another take on the biomarker issue. Perhaps someone can check out the app and report back on if its at all valuable…

Source: https://twitter.com/balajis/status/1706217885251899684

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#23

And from Max, out of Brian Kennedy’s lab:

For a deeper dive - the

@agingbiomarkers

consortium just published a great overview on the aging biomarker space!



https://www.cell.com/cell/pdf/S0092-8674(23)00857-7.pdf

Summer of paper:
https://www.sciencedirect.com/science/article/abs/pii/S0092867423008577

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#24

Can anyone post the article in cell? I can get past the firewall.

#26

Some of it will come from your HR. As HR moves up and down during sleep, your HRV will change dramatically. When your heart beats quickly there isn’t as much time for a lot of variability between beats.

#28

After reading the paper and following the references. We are still screwed in the fact that there are major disagreements on the causes of aging and ameliorating the effects of aging.

“At a recent symposium on aging biology, a debate was held as to whether or not we know what biological aging is. Most of the participants were struck not only by the lack of consensus on this core question but also on many basic tenets of the field. Accordingly, we undertook a systematic survey of our 71 participants on key questions that were raised during the debate and symposium, eliciting 37 responses. The results confirmed the impression from the symposium: there is marked disagreement on the most fundamental questions in the field, and little consensus on anything other than the heterogeneous nature of aging processes”
https://www.sciencedirect.com/science/article/abs/pii/S0047637420301123?via%3Dihub

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#30

Tipped to this by “High Intensity Health” YouTube channel.

Blood biomarker profles and exceptional longevity: comparison of centenarians and non‑centenarians in a 35‑year follow‑up of the Swedish AMORIS cohort

Lots of odd and interesting things to digest from this paper.

"For total cholesterol and iron, higher levels increased the odds, and for glucose, creatinine,

uric acid, ASAT, GGT, ALP, LD, and TIBC lower levels increased the odds of becoming a centenarian."

Yet in the same paper, they say:

" Cross-sectional studies have found centenarians to have lower total cholesterol"

“C-reactive protein (CRP) was an important predictor for exceptional survival” This is implied as the CRP test is not a normally prescribed routine test.

Looking at the charts of the differential between non-centenarians and centenarians, it looks like

glucose, creatinine, uric acid, and GGT (Gamma Glutamyl Transferase) have the highest differentials and may be the most important markers. I have never had a GGT or uric acid test.

I also find this chart odd. Virtually no one has normal ALP levels?

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Blood biomarker profiles and exceptional longevity: comparison of centenarians and non-centenarians in a 35-year follow-up of the Swedish AMORIS cohort | GeroScience.

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#31

It’s the same study we discussed here:

They explain it as the ‘normal’ levels are based on a young cohort so the increase is due to aging:

Most individuals, both centenarians and non-centenarians, had values of ALP and LD outside the range considered normal in clinical guidelines. This is likely due to aging and the presence of age-related health conditions [28], as these guidelines are set based on a younger and healthier population. As such, clinically defined normal ranges might not always reflect the optimum for the oldest old.

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#32

Btw I forgot to mention that low HRV is associated with clinical depression and since you have mentioned anger issues in another post (very common “male type” depression symptom) I would advise you to get screened for depression. Just to rule it out if nothing else.

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#33

I am going to be tracking my mood which includes a depression and anxiety screener in iOS 17 health app.

It looks like this:

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Mostly because I want to maximize wellbeing and I’ll use it to possibly run correlations with other things.
It’s probably the most important part of healthspan.

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#34

If you can boost your low HRV, any mood issues might resolve on their own. For me, sleep and not exercising too hard too often are the key to HRV. I assume you mean sleeping HRV or HRV measured at wakeup while laying in bed. Anything else is too easily confounded.

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#35

For low HRV I’ve found out that 500mg L-Theanine and reducing the bedroom temperature as much as tolerable helps.

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#36

Jonas: apologies for my late answer.

Conventionally the ratio should be less than 3.0 but better is less than 2.0

Besides the absolute number of each, it may also be a question of to what degree neutrophils and lymphocytes are “activated”. Cant say much more am just starting to learn about this.

1 Like
#37

Taking a statin reduces both markers :slight_smile:

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#38

Desertshores is over 80 years old chronologically if I remember correctly, would you @desertshores say that statins have served you well the 30+ years you’ve taken them?

I am kind of getting nervous about my apoB, I will go back on a statin again asap and try to nuke apoB. I won’t go off them unless I am on some other apoB lowering therapy

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#39

Yes, I would say that statins have served me well for 30+ years. This is the last apoB test that I took while I was still taking an atorvastatin 40 mg tablet, commonly known as LIPITOR once a day.
Just because I like to experiment, I am currently taking Ezetimibe. It is not as effective as most statins but will reduce low-density lipoprotein (LDL) by 15 to 22%. I also take Pantethine. The combo has given me a better lipid profile on my last blood test than when I was taking Lipitor.
I have had an apoB test since I stopped taking Lipitor.
IMO: If your doctor recommends to you that you take a statin, your an idiot not to. Just find the one that works for you.

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#40

Stress could raise your cholesterol and is a major contributor to ASCVD.
If you think you will be calmer, just take statins, probably it is better than stress about it. Stress in long run will probably cause more damage than statins could.
But IMO pills are not a replacement for healthy lifestyle. Reasonably good diet, exercise, not smoking, stress management… but it eludes me why are you so fixated on apoB and not on any other health risk factor.

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#41

Low apoB, no heart disease. That’s why. It’s very involved in the atherosclerosis process.

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#42

Combined different lifestyle interventions have a potential to reduce LDL-C up to 70% (if I remember correctly from an article someone shared here in the forum). Seems much better strategy than taking a pill and stress about it. But people are different.

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#43

Percent reduction doesn’t concern me, only what absolute levels the causal process is ongoing or not. It is a different paradigm, not based on acceptance of the disease and trying to lessen the effects, but complete prevention of the disease. That’s also why I don’t think other health factors matter.

#44

And you base this on what?

1 Like