#694

Where/who are you buying this from in India?

#695

Thanks! My main concern is not so much memory, as it is the ability to have focused concentration and alertness for a sustained period of at least several hours. I have trouble with daytime sleepiness.

#696

Just use one of the suppliers recommended by Rapamycin News members.

The brand that I am currently using is:

“Compre Rapamicina Online - Lista de Farmácias Confiáveis ”

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#697

Update: Brad Stanfield didn’t answer. He answered a previous email I sent months ago (on another topic), so for sure he got my email. He recommends a supplement (omega 3) that is proven to cause depression even at low doses, and he apparently doesn’t care :man_shrugging:

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#698

Having rummaged around a bit on this (I do supplement with omega 3 and am not depressed) I think you are right that omega 3 supplementation causes depression in some people.

It would be a good thing to try to pin down because for some people a certain amount of omega 3 is quite helpful. I did some experimentation a few years ago and noticed a positive difference caused by omega 3 which I was at the time taking twice a week. A while ago I moved to daily supplementation.

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#699

For those interested, evidence is here (VITAL trial + meta-analyses): Omega 3 makes me depressed: why?

DHA seems to be the culprit. It would be great to know which people are susceptible to DHA-induced depression. As of today, trial and error is the only way to know. I’m now taking 2 g pure EPA per day and I think it improved my mood a bit (whereas EPA + DHA made me lethargic).

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#700

Its an interesting question. I may review this when I next need to buy Omega 3. OTOH I don’t think I am lethargic or depressed.

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#701

garym37, I’ve tried Noopept several times and never found anything subjectively noticeable. For a couple of years now I’ve found Modafinil at 50 mg useful at times, experimenting with methods of taking it: 1) empty stomach 30 minutes before breakfast, 2) with breakfast, and 3) sublingual 30 minutes after breakfast. With breakfast is more subtle, but still effective. I find it most useful with mood and energy if I get active and stay active most of the day. For me, it has a hangover effect hours later that is eased as long as I remain active outdoors. It doesn’t seem to work well without adequate sleep and nutrition or when used too many days in a row and it may make a bad sleep day feel worse. If used for a number of days in a row a washout period of a week or two could be helpful. Ideally I would be able to use it daily, but that doesn’t work for me.

If I’m going on a 10 mile hike and energy level is a bit low sometimes I’ll take 50 mg mid-morning just before I begin the hike, but not unless I feel the need.

For me, it’s like coffee (caffeine), but with a half-life of 12 or more hours and with potentially irritating side effects like jitteriness, hangover effects and insomnia. So, it’s bit of a double-edged sword. If trying it for the first time I suggest just a few milligrams under the tongue in the early morning on a day with no obligations to see your reactions. Experimentation with small doses at different times can let you see the energy curve effect that works best. You can use a razor blade to cut into quarters and smaller pieces. Different people may react differently.

On a different note related to energy I’m experimenting with Galantamine (Relentless Improvement) 4 mg to 8 mg with breakfast. It seems to improve choline levels in the brain and I think is somewhat beneficial with mental clarity and the feeling of alertness during the day. But, at the same time I’m trying 4 grams glycine + 4 grams NAC in the morning blended with coffee (which can irritate the stomach). I believe I’m noticing more energy and alertness with one or both of these things, but it may just be the coffee – LOL!

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#702

Don’t know about depression, but I had put omega 3 supplements in the same bin as Vit A, Vit E, resveratrol and few others, and that is in the garbage bin. I do however think that foods rich in omega 3 are very healthy (i.e. wild salmon).

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#703

I’m not sure omega 3 supplementation should go to the bin. There seems to be a case for it but the devil is in the details (EPA or DHA? Dose? Differences based on APOE4 status or baseline serum levels?). See for instance:

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#704

I believe Omega 3’s are very healthy but never felt good about it in supplement form for some reason, while eating salmon felt amazing. I took it to mean it works better when mixed with protein and other nutrients as opposed to be taken alone as a supplement.

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#705

Yes the quality of the supplements is also an issue. If you can reach the top quintiles for serum DHA and EPA with nutrition only, that’s perfect. Despite eating salmon and sardines frequently, my serum EPA was still low (while DHA was high) so I chose to supplement with pure EPA. I’ll measure again in 4 months to see if I fixed the deficiency.

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#706

Jay, thanks for your detailed post. I save modafinil for special occasions because, while it does perform as advertised, I get all the side effects you mentioned; and they are too unpleasant for regular use. Though I dread adding to my stack, I am going to take a look at Galantamine.

#708

garym37, Galantamine is still experimental for me. I can’t yet say that I’ll keep it because I’m not sure that it provides enough benefit at 4 mg to 8 mg in the morning. After trying it once in the evening with resulting insomnia, that will not happen again. But, I may try morning and noon to see if there is better benefit twice daily. I think it’s providing better alertness in the early to mid-afternoon with that single morning dose, but it’s a subtle effect I’ll have to verify by stopping for a few days then restarting a few times to be sure. Then, it would be on to the twice a day trial.

As an extra note, DesertShores’ suggestion for Memantine Hydrochloride And Donepezil combined (Donamem) looks interesting in that Donepezil and Galantamine work in a similar manner. But, I believe galantamine has a half-life of 8 hours and donepezil + memantine more like 60+ hours half-life making donepezil + memantine a once daily pill versus galantamine’s probable need for several doses daily. That’s speculation, but I will investigate Donamem with ChatGPT for MOA, effects and side effects both short-term and long-term. And, as an “extra” extra note I will definitely not discuss this with my doctor because who knows what happens if an insurance company hears you’re experimenting with Alzheimer’s drugs. LOL!

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#709

Screenshot_2024-12-04-20-37-53-25_f9ee0578fe1cc94de7482bd41accb329
Screenshot_2024-12-04-20-37-53-25_f9ee0578fe1cc94de7482bd41accb3291941×1078 170 KB

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#710

Isn’t it good to presume that salmon and sardines have the same effect as DHA supplements since they are high in them?

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#711

In every single video Dr. Brad makes, he says “just because I take a supplement, does not mean that you should too.”

He never makes supplement recommendations to anyone. Just puts the info out there based on the evidence.

He only made the Microvitamin because he took the ingredients in it himself and wanted to cut down on having to take multiple bottles. The sales have gone towards his Rapamycin study.

There are a lot of snake oil salesmen out there but he is definitely not one of them.

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#712

Nope, not at all. It is easily ten’s or even maybe hundreds of other ingredients/nutrients in Salmon which may (or may not) work synergically with DHA. The supplement does not have such “other” . nutrients. The reason I make the distinction is because every time I eat salmon my inflammation goes to zero lol. No inflamed joints nor fingers or other body parts. As for Omega3 I have NEVER felt such effect. That is NOT to say it may not be good for other purposes, but I simply had ZERO benefits that I could tell. As such it’s been over three years that I stopped taking it and threw away what was left on the bottle. I decided to replace it with one tablespoon of organic EVO each morning, and I can definitely tell a positive impact. I think I made the right choice and NOT looking back.
BTW, I don’t know if reputable or not, but I have run onto couple places/videos/doctors saying that Omega3 supplement are overrated. To each their own, but if something is not doing anything good that I can tell, I scrap it and never look back. There are over 500 substances/supplements out there that one can experiment on. Not willing to waste my time on things I feel ZERO effect from.

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#713

On that note, now that I’m starting to take more and more things (you guys are contagious!), I was just saying there must be supplement service to custom make pills so we can cut down on the number of capsules! They all seem to have fillers, so it seems there is room for more of the stuff we want in there. (Perhaps fillers have a useful purpose).

I knew not to bother searching because it seems too good to be true and would be prohibitively expensive, but your response nudged me to google and, by George, it exists!

I guess aside from cost, quality/trust would be the only issue.

Has anyone ever looked at any of these companies? I clicked on a random one called getvitaminlab.com

There is zero chance we could all agree on anything, but now I’m thinking bigger and commissioning our own supplements for our group would get us a nice discount :). We could be our own Brad. (If we could agree on ingredients, I’d actually want to do this!)

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#714

If I say: “I think that investing in company Y could lead to a return on investment of N over the next years based on these papers and that’s why I personally invested in company Y. But just because I incest in company Y, it does not mean you should.” Then the disclaimer is worthless and intellectually dishonest. If the papers show it’s good and I personally invest, why wouldn’t other people do it as well?

The issue is that he does not give reasons why you should NOT take the supplements (or invest if we keep the example).

He should, after each supplement, mention a reason NOT to take it. And then, yes, people would be left with the evidence and would make their own decisions.

For instance, for omega 3, despite dozens of papers showing that it causes depression, he doesn’t mention it. He didn’t answer my email about this.

That being said, Brad Stanfield is definitely not a snake oil salesman; he’s great, and he’s still one of the best “longevity influencers” (but the bar is pretty low).

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