My rationale for taking CoQ10 is not to offset or prevent myalgia, but rather to replace a likely important coenzyme. My thinking is that since drugs (in this case my rosuvastatin) are systemic, along with their intended target effects (lowering ApoB) they have unintended consequences on unintended targets in the body (in this case reducing production of CoQ10). However, at the same time, I appreciate any reason to add another supplement to my supplement graveyard under my sink.
Coenzyme Q10 and Statin-Induced Mitochondrial Dysfunction - PMC.
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That is a well designed and executed research protocol.
KarlT
#23
I donāt think there is any downside to taking CoQ10 other than cost. Dr Stanfield says itās gener not needed in people on statins. Dr Attia says that if statins have any impact on mitochondria, it is negligible. Any significant change in CoQ10 would impact mitochondria.
My personal goal is to minimize how many supplements I take.
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This is my goal also. To do this I try to prioritize according to this 2x2 grid (I go for the high & high sector):
(1) My personal needs for improvement: high vs. low (this is fairly easy within the limits of my understanding; I can target specific blood markers fairly easily but targeting more fundamental issues such as mitochondrial dysfunction which is causing blood marker issues is more challenging). Of course my first effort is in diet, sleep, exercise, etc. before resorting to long-term supplementation.
(2) Supplement efficacy to accomplish a goal: high vs. low (this is harder; and my personal experience may be different from the results of scientific studies, so a lot of trial and error is to be expected).
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Is this an old quote from Attia? I could believe he said that a few years ago when he took a statin. Iām confident statins do interfere with mitochondria, and that the extent or downstream impact of the interference may vary by person but ānegligibleā in general seems incorrect.
Coq10 supplementation never did anything for me but GG was a game changer when I took low dose statin (5mg rosuvastatin EOD).
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AnUser
#26
No, itās recent like from his interview by Rhonda Patrick.
Zone 2 wattage didnāt change on/off statin for his patients, so impact on mitochondria if any is not relevant in general. YMMV
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@RobTuck check out this thread for GG details. It worked for me.
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blsm
#29
Nearly all of them tbh. In the past I messed myself with too high of doses or the wrong forms of certain vitamins (for me personally) which certainly isnāt applicable to everyone and was just due to prior ignorance but since then Iāve been careful with vitamin and mineral pills. Last year I took a class that helped me learn how increase the nutrient density of my diet so I thankfully no longer feel I need vitamin/mineral supplements. I still take Creatine and melatonin though. The rest of my current fairly minimalist longevity stack is either pharmaceuticals or lifestyle measures.
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LukeMV
#30
I used to buy literally every supplement. If I read one good article, Iād immediately order it. I didnāt really know how to read studies at first so I believed everything and anything. I would read Life Extension magazine every month and order everything they wrote an article about. I had a health scare so I went deep into supplements, essentially out of fear. Things have definitely changed now.
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RobTuck
#31
What dose of GG are you taking?
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I stopped taking Apigenin. I have 5 capsules left and will just finish them off. Supposedly it lowers CD38 levels in the blood, but I could see nothing in my bloodwork that changed because of it.
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Perhaps dropping those supplements which are sourced in China, and here is reason 1trillion768 to avoid ingesting any and all products from that country, whether food, supplements or medications:
Of course, sadly it is impossible to avoid products from China, as most if not all supp companies source ingredients from China one way or another.
But to the degree that one can avoid it, I think itās a good idea to. I know that āfrom Chinaā is definitely a strong consideration in my decision whether to take a certain supplement, or not. YMMV.
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@RobTuck I was taking 150mg per day that I exercised. Hereās the new 300mg version thatās cheaper than the original. I no longer take it now that I donāt take a statin.
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RobTuck
#35
Thanks @Joseph_Lavelle . I guess the thinking is that the supplement does not add significant value other than its role for making it possible for some people to stay on statins.
@RobTuck I wouldnāt assume that. I think the idea is to help with the electron transport chain function more efficiently. ā¦to help the mitochondria make more ATP with less ROS.
I can say that it had such a profound effect for me that I would recommend it to anyone who is looking to improve mitochondria function. I only donāt take it because I donāt feel a need for it. I am not having obvious issues (weakness, brain fog) or pushing my body so hard that I am having trouble recovering.
But I will go back to it when I need it. Definitely.
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No longer take melatonin. Creatine was a fail ā bloated terribly. Hyaluronic Acid (oral) ā itchy. Have dropped many others or only take very intermittently. The remaining set is still large-- magnesium, taurine, GABA, D3, C, Benfotiamine, Boswellia, K2MK7 ad MK4, Cholestoff (plant sterols/stanols) chondroitin/glucosamine, berberine, passionflower tea and tincture, PQQ and a few others in the core set and āseveralā on rotation.
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I want to try creatine HCL next because I also canāt tolerate creatine monohydrate at all.
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Melih
#39
Yeah Iām so confused. Creatine never made me bloated when I was a teen (15-18), suddenly it started to bloat me. Could it be contaminated?
RobTuck
#40
Hormonal differences would be one line of investigation.
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